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  1. Introduction to toxicology

    • What is toxicology and why is it important?

    Back to basics

    • Cells, tissues, organs, organ systems
    • Homeostasis, adaptation and cell injury
    • Adverse effects
    • Local and systemic effects

    Exposure and dose

    • Risk, hazard and exposure – how these differ
    • The dose makes the poison – thresholded and non thresholded effects

    Dose response curves

    • Dose response and dose-effect relationships and curves
    • Internal and external/exposure dose

    How chemicals cause harm – local effects

    • Irritation and corrosion (skin, eyes, respiratory tract)

    How chemicals cause harm – systemic effects

    • Target organ toxicity, reproductive and developmental effects, carcinogenicity, genetic toxicology, skin and respiratory sensitisers (chemical allergies).

    Basic toxicokinetics

    • Absorption, distribution, metabolism and excretion
    • How knowledge of toxicokinetics can help in understanding species differences in response to chemical exposure

    Assessment of toxicity

    • Use of animal and non-animal alternatives
    • In vitro, in vivo, ex vivo and in silico methods

    Introduction to human health risk assessment

    • How toxicology and an understanding of exposure is used in risk assessment work
    Laura Robinson Laura Robinson
    Occupational Toxicologist, Toxicology Consulting Ltd, UK
  2. Finish