Event overview

The webinar will cover:

1)  Introduction to target organ toxicity and its use in chemical risk assessment and classification and labelling (CLP/GHS).

2)  The Liver as a target organ

  • The structure and function of the liver (including its role in metabolism)
  • Adaptive responses of the liver and their significance to human exposure
  • Why the liver is commonly a target organ for toxicity and how it responds to chemical injury (necrosis, cirrhosis, steatosis, cholestasis and hepatocarcinogenesis)
  • Assessment of liver function (including common indicators of injury)

3)  The kidney as a target organ

  • The structure and function of the kidneys
  • Why the kidneys are a common target organ for toxicity
  • How chemicals cause injury to the kidneys (damage to glomeruli, tubules and other effects)
  • Assessment of renal function (including common indicators of injury)

4)  The Nervous System as a target organ

  • Introduction to the structure and function of the nervous system (central nervous system, peripheral nervous system the cells of the nervous system and the blood brain barrier)
  • How information is transmitted within the nervous system (development of action potentials, and neurotransmitters)
  • The nervous system as a target organ – neurotoxins, neuropathy, axonopathy, myelinopathy, interference with neurotransmitters
  • Developmental neurotoxicity
  • Assessment of neurotoxicological effects

The Webinar will last for 90 minutes with opportunity to ask questions throughout the session. Full lecture notes (in the form of a manual) are included together with a copy of the presentation slides. Note, an introductory/basic toxicology background would be of use for this particular Webinar.