Event overview
The webinar will cover:
1) Introduction to target organ toxicity and its use in chemical risk assessment and classification and labelling (CLP/GHS).
2) The Liver as a target organ
- The structure and function of the liver (including its role in metabolism)
- Adaptive responses of the liver and their significance to human exposure
- Why the liver is commonly a target organ for toxicity and how it responds to chemical injury (necrosis, cirrhosis, steatosis, cholestasis and hepatocarcinogenesis)
- Assessment of liver function (including common indicators of injury)
3) The kidney as a target organ
- The structure and function of the kidneys
- Why the kidneys are a common target organ for toxicity
- How chemicals cause injury to the kidneys (damage to glomeruli, tubules and other effects)
- Assessment of renal function (including common indicators of injury)
4) The Nervous System as a target organ
- Introduction to the structure and function of the nervous system (central nervous system, peripheral nervous system the cells of the nervous system and the blood brain barrier)
- How information is transmitted within the nervous system (development of action potentials, and neurotransmitters)
- The nervous system as a target organ – neurotoxins, neuropathy, axonopathy, myelinopathy, interference with neurotransmitters
- Developmental neurotoxicity
- Assessment of neurotoxicological effects
The Webinar will last for 90 minutes with opportunity to ask questions throughout the session. Full lecture notes (in the form of a manual) are included together with a copy of the presentation slides. Note, an introductory/basic toxicology background would be of use for this particular Webinar.