Agenda
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Understanding the guidance for identifying endocrine disrupting chemicals
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Workshop leaders:
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Introduction on endocrine disruptors: regulatory background, history, criteria and guidance
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Stepwise approach: overview on the main requirements of the new guidance
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First steps: Gathering and assembly of data – targeted literature search, data bases, QSAR profiling and reporting of data
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Investigation of ED properties with a focus on EATS endpoints: Specific toxicological and ecotoxicological study types
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Coffee break
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Identification and assessment of ED properties for human health and environment: evaluation of all available data
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Assembly of the lines of evidence, evaluation of completeness of data
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Weight of evidence evaluation: bringing together an overall argumentation
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Mode of Action Analysis – assessing the biological plausible link between observed effects and ED activity
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Lunch
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Regulatory consequences for applicants and overall implications on dossier preparation: Derogations human health/environment
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Discussion
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End of workshop
