Programme
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An Introduction to Reproductive and Development Toxicology
- Differences between reproductive and developmental toxicity
- Ways in which chemical exposure may interfere with the normal reproductive and developmental processes
- Key elements of the male and female reproductive system
- Role hormones play in the reproductive process (endocrine system)
- Terms endocrine disruptor, endocrine active substance, possible endocrine disruptor
- Criteria which are currently used for the identification of endocrine disruptors
- Process of fertilisation and the difference between embryonic and foetal stages
- Why organogenesis is such a critical time period in the developmental process
- Difference between teratogen, congenital malformation and teratology and what is meant by maternal mediated effects
- How chemicals can cause effects on the reproductive and developmental process and the current approach which is taken in their assessment (QSAR, human evidence, in vitro, in vivo studies - one generation, two generation, extended one generation reproductive toxicity studies and prenatal developmental toxicity studies)
- What is meant by delayed ossification, wavy ribs and malformations
