Learning outcomes
At the end of the webinar you will be able to
- Explain the difference between toxicokinetics and toxicodynamics
- Outline the ways in which knowledge of toxicokinetics is so useful
- Explain what is meant by the acronym ‘ADME’
- Describe what happens during absorption and the ways in which physicochemical properties can be used in predicting the extent of absorption
- Explain what is meant by ‘ionisation’ and ‘polar/non-polar’ molecules
- Explain what is meant by ‘first pass metabolism’ and how this influences toxicity
- Explain the significance of absorption by the intravenous route and intraperitoneal route.
- Define the term ‘bioavailability’ and its significance to toxicity
- Explain what is meant by distribution and how this can impact toxicity.
- Define the term ‘apparent volume of distribution’ and its significance
- Outline the role of metabolism (phase 1 and phase 2) and its relationship to toxicity (with specific reference to benzene and paracetamol as examples)
- Explain the significance of hepatic injury/disease to the metabolic process
- Explain the significance of intraspecies variations and what is meant by this
- Define the term ‘excretion/elimination’ and the way in which elimination kinetics is used (zero order and first order) with specific examples
- Explain what is meant by the biological half-life of a chemical and its significance
- Explain how the area under the curve can be used (AUC) to assess bioavailability
- Outline current methods which are available for the assessment of toxicokinetics and current regulatory requirements.