At the end of the webinar you will be able to:

Mutagenicity and genotoxicity

  • Explain the difference between genotoxicity and mutagenicity
  • Describe the structure of DNA, what is meant by chromosomes and genes
  • Explain what is meant by cell replication, why it is needed, how it occurs and how it is controlled
  • Explain the difference between gene mutations and chromosomal abnormalities and other types of DNA damage.
  • Explain the consequences of mutations in somatic cells compared to germ cells
  • Outline the aim of genetic toxicity testing and the approach which is taken in the assessment. (In vitro, in vivo, controls, cytotoxicity,etc) for both somatic cell and germ cell mutagenicity
  • Explain the approach used for the evaluation of results


  • Define what is meant by cancer, carcinogenesis, tumour, neoplasm
  • Describe the different between a normal cell and a neoplastic cell
  • Explain the difference between a benign and malignant tumour
  • Outline the stages for the development of a cancer and the genetic drivers of cancer
  • Describe what is meant by the ‘hallmarks of cancer
  • Outline the causes of cancer and the issues with regard to its identification
  • Explain the current approach which is used to identify carcinogens (QSAR, epidemiological studies, genetic toxicity studies, in vitro studies and animal studies
  • Outline the important considerations when interpreting results
  • Be able to apply the current classification and labelling criteria in accordance with EU CLP and GHS for carcinogenicity and mutagenicity