At the end of the webinar you will be able to:

Mutagenicity and genotoxicity

Explain the difference between genotoxicity and mutagenicity
Describe the structure of DNA, what is meant by chromosomes and genes
Explain what is meant by cell replication, why it is needed, how it occurs and how it is controlled
Explain the difference between gene mutations and chromosomal abnormalities and other types of DNA damage.
Explain the consequences of mutations in somatic cells compared to germ cells
Outline the aim of genetic toxicity testing and the approach which is taken in the assessment. (In vitro, in vivo, controls, cytotoxicity,etc) for both somatic cell and germ cell mutagenicity
Explain the approach used for the evaluation of results

Carcinogenesis

Define what is meant by cancer, carcinogenesis, tumour, neoplasm
Describe the different between a normal cell and a neoplastic cell
Explain the difference between a benign and malignant tumour
Outline the stages for the development of a cancer and the genetic drivers of cancer
Describe what is meant by the ‘hallmarks of cancer
Outline the causes of cancer and the issues with regard to its identification
Explain the current approach which is used to identify carcinogens (QSAR, epidemiological studies, genetic toxicity studies, in vitro studies and animal studies
Outline the important considerations when interpreting results
Be able to apply the current classification and labelling criteria in accordance with EU CLP and GHS for carcinogenicity and mutagenicity