Toxicology for Non-Toxicologists

• What are the toxicological requirements under REACH and why?
• What is toxicology?
• The Safety Data Sheet

Toxicological themes

• Systemic effects (target organ effects, carcinogenicity, mutagenicity and developmental effects)
• Risk, hazard and exposure
• The dose response concept & Paracelsus
• Acute and chronic toxicity
• Local effects (irritation and corrosion)
• Chemical allergy
• Use of animal/non animal testing strategies
• Hazard and exposure

Toxicology in the context of REACH

• The safety data sheet and eSDS
• The DNEL
• CLP/GHS

Laura Robinson

Occupational Toxicologist, Toxicology Consulting Ltd, UK