Learning outcomes

    At the end of the Toxicokinetics webinar you will be able to:

    • Explain the difference between toxicokinetics and toxicodynamics
    • Outline the ways knowledge of toxicokinetics can be used in your daily work
    • Explain what is meant by the acronym ‘ADME’
    • Describe what happens during absorption and the ways in which physicochemical properties can be used in predicting the extent of absorption
    • Explain what is meant by ‘ionisation’ and ‘polar/non-polar’ molecules
    • Explain what is meant by ‘first pass metabolism’ and how this influences toxicity
    • Explain the significance of absorption by the intravenous route and intraperitoneal route
    • Define the term ‘bioavailability’ and its significance to toxicity
    • Explain what is meant by distribution and how this can impact toxicity.
    • Define the term ‘apparent volume of distribution’ and its significance
    • Outline the role of metabolism (phase 1 and phase 2) and its relationship to toxicity (with specific reference to benzene and paracetamol as examples)
    • Explain the significance of hepatic injury/disease to the metabolic process
    • Explain the significance of intraspecies variations and what is meant by this
    • Define the term ‘excretion/elimination’ and the way in which elimination kinetics is used (zero order and first order) with specific examples
    • Explain what is meant by the biological half-life of a chemical and its significance
    • Explain how the area under the curve can be used (AUC) to assess bioavailability
    • Outline current methods which are available for the assessment of toxicokinetics and current regulatory requirements.
    Laura Robinson Trainer: Laura Robinson
    Occupational Toxicologist, Toxicology Consulting Ltd, UK