Programme

  1. Registration

  2. Course Commencement

    Introduction to toxicology

    • What is toxicology and why is it important?
    • Risk, hazard and exposure – how these differ
    • Dose response and dose-effect relationships & curves
    • Internal and external/exposure dose
    • NOAEL, LOAEL
    • Thresholded and non thresholded effects

    Basic toxicological terminology and concepts

    • Cells, tissues, organs, organ systems
    • Homeostasis
    • Adaptation and cell injury
    • Cellular responses to injury
    • Adverse effects
    • Local and systemic effects
    • Acute and chronic toxicity
  3. Refreshment break

  4. How chemicals cause harm - Local effects

    • Irritation and corrosion (skin, eyes, respiratory tract)

    How chemicals cause harm -Systemic effects

    • Target organ toxicity, reproductive and developmental effects, carcinogenicity, genetic toxicology, Skin and respiratory sensitisers (chemical allergies),
  5. Lunch

  6. How chemicals cause harm - Systemic effects (continued)

    • Target organ toxicity, reproductive and developmental effects, carcinogenicity, genetic toxicology, Skin and respiratory sensitisers (chemical allergies),

    Basic Toxicokinetics

    • Absorption, distribution, metabolism and excretion
    • How knowledge of toxicokinetics can help in understanding species differences in response to chemical exposure
  7. Refreshment break

  8. Assessment of toxicity

    • Alternative methods
    • Acute toxicity testing
    • Repeated dose toxicity testing
    • Genetic toxicity studies
    • Carcinogenicity studies
    • Reproductive and developmental toxicity studies
    • Sensitisation studies
    • Common design of toxicity studies (control, replicates, etc)
    • Limitations of toxicity testing
  9. Questions

  10. Close of day

  11.  

    Course leader:

    Laura Robinson Laura Robinson
    Occupational Toxicologist, Toxicology Consulting Ltd