Agenda
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Topics Covered
Introduction to toxicology
- What is toxicology and why is it important?
Back to basics
- Cells, tissues, organs, organ systems
- Homeostasis, adaptation and cell injury
- Adverse effects
- Local and systemic effects
Exposure and dose
- Risk, hazard and exposure – how these differ
- The dose makes the poison - thresholded and non thresholded effects
Dose response curves
- Dose response and dose-effect relationships & curves
- Internal and external/exposure dose
- NOAEL, LOAEL
How chemicals cause harm - Local effects
- Irritation and corrosion (skin, eyes, respiratory tract)
How chemicals cause harm - Systemic effects
- Target organ toxicity, reproductive and developmental effects, carcinogenicity, genetic toxicology, Skin and respiratory sensitisers (chemical allergies).
Basic Toxicokinetics
- Absorption, distribution, metabolism and excretion
- How knowledge of toxicokinetics can help in understanding species differences in response to chemical exposure
Assessment of toxicity
- Use of animal and non-animal alternatives
- In vitro, in vivo, ex vivo and in silico methods
Introduction to human health risk assessment
- How toxicology and an understanding of exposure is used in risk assessment work
