Agenda

  1. An Introduction to Reproductive and Development Toxicology

    • Differences between reproductive and developmental toxicity
    • Ways in which chemical exposure may interfere with the normal reproductive and developmental processes
    • Key elements of the male and female reproductive system
    • Role hormones play in the reproductive process (endocrine system)
    • Terms endocrine disruptor, endocrine active substance, possible endocrine disruptor
    • Criteria which are currently used for the identification of endocrine disruptors
    • Process of fertilisation and the difference between embryonic and foetal stages
    • Why organogenesis is such a critical time period in the developmental process
    • Difference between teratogen, congenital malformation and teratology and what is meant by maternal mediated effects
    • How chemicals can cause effects on the reproductive and developmental process and the current approach which is taken in their assessment (QSAR, human evidence, in vitro, in vivo studies - one generation, two generation, extended one generation reproductive toxicity studies and prenatal developmental toxicity studies)
    • What is meant by delayed ossification, wavy ribs and malformations
    Laura Robinson Laura Robinson
    Occupational Toxicologist, Toxicology Consulting Ltd, UK